SCHEMBL19035489

SCHEMBL19035489

COc1ccc(F)c(-c2ncc(COc3cccc(C(CC(=O)O)C4CC4)c3)nc2OCC(C)C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17418589 1.00 FFAR1 (1.00) FFAR1
SCHEMBL19035520 0.92 FFAR1 (1.00) FFAR1
SCHEMBL17418781 0.92 FFAR1 (1.00) FFAR1
SCHEMBL19035484 0.91 FFAR1 (1.00) FFAR1
SCHEMBL17418958 0.91 FFAR1 (1.00) FFAR1
SCHEMBL17418558 0.90 FFAR1 (1.00) FFAR1
SCHEMBL19035485 0.90 FFAR1 (1.00) FFAR1
SCHEMBL19035465 0.90 FFAR1 (1.00) FFAR1
SCHEMBL17419073 0.90 FFAR1 (1.00) FFAR1
SCHEMBL16319165 0.90 FFAR1 (0.82) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9688642-B2 Substituted pyrazines as GPR40 agonists JANSSEN PHARMACEUTICA NV (BE) 2017-06-27 US disclosed