Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.61 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19022755 | 1.00 | CHRM4 (0.61) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19037452 | 0.93 | CHRM4 (0.72) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19022911 | 0.93 | CHRM4 (0.72) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19023273 | 0.93 | CHRM4 (0.72) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19022862 | 0.87 | CHRM4 (0.61) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19050000 | 0.84 | CHRM4 (0.83) | CHRM4PRMT5WDR77KDM2BGPR6 | |
| SCHEMBL19023255 | 0.84 | CHRM4 (0.83) | CHRM4PRMT5WDR77KDM2BGPR6 | |
| SCHEMBL19022661 | 0.83 | CHRM4 (0.40) | CHRM4PRMT5WDR77CYP2D6HRH3 | |
| SCHEMBL19050014 | 0.81 | CHRM4 (0.78) | CHRM4PRMT5WDR77KDM2BGPR6 | |
| SCHEMBL19022738 | 0.81 | CHRM4 (0.78) | CHRM4PRMT5WDR77KDM2BGPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170183342-A1 | 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME LLC | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183342-A1 | 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | CHRM5, CHRM4, CHRM1 | CHRM4 2/4885PRMT5 171/4885WDR77 1345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.