SCHEMBL1904028 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	AKT1	P31749	7/20	0.37

▸	PORCN	Q9H237	4/20	0.36

▸	TACR3	P29371	2/20	0.34

▸	CYP2D6	P10635	2/20	0.34

▸	AKT2	P31751	2/20	0.33

▸	HDAC8	Q9BY41	1/20	0.33

▸	ABL1	P00519	1/20	0.33

▸	PDE11A	Q9HCR9	1/20	0.33

▸	PDE2A	O00408	2/20	0.33

▸	ALOX5AP	P20292	1/20	0.32

▸	ALOX5	P09917	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12095518	0.95	AKT1 (0.34)	AKT1PORCNTACR3CYP2D6AKT2
SCHEMBL14118948	0.91	AKT1 (0.41)	AKT1PORCNAKT2PDE2A
SCHEMBL14118957	0.88	TACR3 (0.41)	AKT1TACR3PDE2A
SCHEMBL1907030	0.87	CHEK1 (0.36)	AKT1TACR3AKT2PDE2AALOX5AP
SCHEMBL1903041	0.86	AKT1 (0.38)	AKT1TACR3PDE2A
SCHEMBL1900984	0.86	AKT1 (0.40)	AKT1TACR3AKT2ABL1PDE2A
SCHEMBL14119198	0.85	AKT1 (0.33)	AKT1TACR3
SCHEMBL1906672	0.85	TACR3 (0.38)	AKT1TACR3PDE2A
SCHEMBL1900154	0.84	AKT1 (0.46)	AKT1AKT2
SCHEMBL14118904	0.84	TACR3 (0.37)	AKT1TACR3PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011055115-A1	AKT / PKB INHIBITORS	ALMAC DISCOVERY LIMITED (GB)	2011-05-12	—	—	WO	disclosed