Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1904306 | 0.98 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBHSD17B10CXCR4MAPT | |
| SCHEMBL21581307 | 0.88 | CXCR4 (0.46) | SMN1; SMN2POLBHSD17B10CXCR4MAPT | |
| SCHEMBL21581285 | 0.86 | CXCR4 (0.47) | SMN1; SMN2POLBHSD17B10CXCR4MAPT | |
| SCHEMBL21581275 | 0.85 | CXCR4 (0.50) | SMN1; SMN2POLBHSD17B10CXCR4MAPT | |
| SCHEMBL7114925 | 0.84 | — | — | |
| SCHEMBL28303412 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBHSD17B10CXCR4ANPEP | |
| SCHEMBL6424566 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBHSD17B10CXCR4ANPEP | |
| SCHEMBL1408746 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBHSD17B10CXCR4ANPEP | |
| SCHEMBL3488699 | 0.80 | MAPT (0.60) | SMN1; SMN2POLBHSD17B10MAPTATM | |
| SCHEMBL22320733 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBHSD17B10CXCR4ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229163-B | Method for synthesizing hydroxyalkyl triethylene diamine compound | 嘉兴润博化工科技有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-110229163-A | A kind of hydroxy alkyl triethylenediamine class compound synthesis method | 嘉兴润博化工科技有限公司 | 2019-09-13 | — | — | CN | claimed |
| CN-110229163-B | Method for synthesizing hydroxyalkyl triethylene diamine compound | 嘉兴润博化工科技有限公司 | 2022-05-24 | — | — | CN | disclosed |
| CN-110229163-A | A kind of hydroxy alkyl triethylenediamine class compound synthesis method | 嘉兴润博化工科技有限公司 | 2019-09-13 | — | — | CN | disclosed |
| WO-2014082889-A1 | NOVEL IMIDAZOLINES AS DUAL INHIBITORS OF MDM2 AND MDMX | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-05 | — | — | WO | disclosed |
| US-20140148443-A1 | Novel Imidazolines as dual inhibitors of MDM2 and MDMX | HOFFMANN-LA ROCHE INC. (US) | 2014-05-29 | — | — | US | disclosed |
| EP-2203437-B1 | CHIRAL CIS-IMIDAZOLINES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |
| EP-2325180-A1 | Chiral CIS-imidazolines | F. Hoffmann-La Roche AG (CH) | 2011-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148443-A1 | Novel Imidazolines as dual inhibitors of MDM2 and MDMX | MDM2, MDM4, TP53 | SMN1; SMN2 2225/4885POLB 3529/4885HSD17B10 4365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.