Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.72 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29935321 | 0.84 | IRAK4 (1.00) | IRAK4SYKIRAK1 | |
| SCHEMBL19029999 | 0.84 | IRAK4 (1.00) | IRAK4SYKIRAK1 | |
| SCHEMBL23277924 | 0.79 | IRAK4 (0.73) | IRAK4 | |
| SCHEMBL19045425 | 0.79 | IRAK4 (0.73) | IRAK4 | |
| SCHEMBL19030146 | 0.71 | IRAK4 (1.00) | IRAK4SYKIRAK1 | |
| SCHEMBL19030252 | 0.68 | IRAK4 (0.50) | IRAK4 | |
| SCHEMBL19030716 | 0.65 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL19030104 | 0.64 | IRAK4 (0.49) | IRAK4 | |
| SCHEMBL19030764 | 0.64 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL19030025 | 0.64 | IRAK4 (1.00) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |