Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23277908 | 0.84 | IRAK4 (0.46) | IRAK4 | |
| SCHEMBL19030855 | 0.82 | MAPT (0.42) | GPR183IRAK4SCD5CYP11B2HDAC1 | |
| SCHEMBL19045415 | 0.81 | GPR183 (0.45) | GPR183SCD5CYP11B2HDAC1HDAC2 | |
| SCHEMBL19046181 | 0.79 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL19046023 | 0.79 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL20594546 | 0.74 | SMARCA2 (0.45) | IRAK4 | |
| SCHEMBL20594509 | 0.71 | MAPT (0.52) | IRAK4 | |
| SCHEMBL19045908 | 0.69 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL19030728 | 0.69 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL19030463 | 0.69 | MAPT (0.48) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |