Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046183 | 0.91 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL19044605 | 0.87 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL19045314 | 0.87 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19045816 | 0.84 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL19045364 | 0.83 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL19044580 | 0.83 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL19045114 | 0.81 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19046135 | 0.80 | IRAK4 (0.42) | IRAK4 | |
| SCHEMBL19045810 | 0.80 | IRAK4 (0.50) | IRAK4 | |
| SCHEMBL19045343 | 0.80 | IRAK4 (0.54) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |