Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.43 |
| ▸ | OGA | O60502 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046180 | 0.87 | IRAK4 (0.46) | IRAK4OGAHSD17B10 | |
| SCHEMBL19045021 | 0.81 | IRAK4 (0.42) | IRAK4OGADRD2KDM4EALDH1A1 | |
| SCHEMBL19030390 | 0.78 | IRAK4 (0.49) | IRAK4 | |
| SCHEMBL19030309 | 0.75 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL19030014 | 0.74 | IRAK4 (0.48) | IRAK4ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL19046003 | 0.73 | IRAK4 (0.55) | IRAK4 | |
| SCHEMBL19046022 | 0.72 | OGA (0.35) | IRAK4OGAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19030797 | 0.71 | IRAK4 (0.51) | IRAK4ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL19045338 | 0.71 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL21326705 | 0.70 | IRAK4 (0.51) | IRAK4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |