Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23277898 | 0.77 | AKR1B1 (0.34) | ALDH1A1MAPTKDM4EIRAK4 | |
| SCHEMBL19030704 | 0.74 | CYP1A2 (0.39) | ALDH1A1MAPTKDM4E | |
| SCHEMBL23277936 | 0.68 | IRAK4 (0.46) | IRAK4 | |
| SCHEMBL19045702 | 0.67 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19045683 | 0.67 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL23277962 | 0.67 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL23277920 | 0.67 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL19046104 | 0.67 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL19046113 | 0.67 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL19046127 | 0.66 | IRAK4 (0.49) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK1, IRAK4, IRAK2 | ALDH1A1 1146/4885MAPT 1916/4885KDM4E 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.