Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046332 | 1.00 | IRAK4 (0.46) | IRAK4HTR2A | |
| SCHEMBL29935220 | 1.00 | IRAK4 (0.46) | IRAK4HTR2A | |
| SCHEMBL19046129 | 0.85 | IRAK4 (0.47) | IRAK4HTR2A | |
| SCHEMBL19045707 | 0.83 | HTR2A (0.37) | IRAK4HTR2A | |
| SCHEMBL19046305 | 0.82 | IRAK4 (0.56) | IRAK4HTR2A | |
| SCHEMBL23277936 | 0.81 | IRAK4 (0.46) | IRAK4HTR2A | |
| SCHEMBL19045694 | 0.79 | IRAK4 (0.51) | IRAK4HTR2A | |
| SCHEMBL23277915 | 0.79 | IRAK4 (0.51) | IRAK4HTR2A | |
| SCHEMBL19030426 | 0.79 | IRAK4 (0.51) | IRAK4HTR2A | |
| SCHEMBL19029967 | 0.79 | IRAK4 (0.45) | IRAK4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |