Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lenalidomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN known ✓ | Q96SW2 | 13/20 | 0.97 |
| ▸ | DDB1 known ✓ | Q16531 | 3/20 | 0.97 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.97 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.97 |
| ▸ | TNF | P01375 | 3/20 | 0.97 |
| ▸ | IL1B | P01584 | 3/20 | 0.97 |
| ▸ | BRD4 | O60885 | 1/20 | 0.97 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.52 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lenalidomide SCHEMBL18917501 | 1.00 | CRBN (0.97) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL18917500 | 1.00 | CRBN (0.97) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL31329263 | 1.00 | CRBN (0.97) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL16107378 | 0.99 | CRBN (0.95) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL10192650 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL10192663 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL30876939 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL10192655 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL868339 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF | |
| Lenalidomide SCHEMBL18825 | 0.99 | CRBN (1.00) | CRBNIKZF3IKZF1DDB1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119371400-A | Lenalidomide amination Process for the preparation of a compound | 南京亿华药业有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-108218833-A | A kind of preparation method of lenalidomide | 王琰萍 | 2018-06-29 | — | — | CN | disclosed |
| US-20170157103-A1 | METHODS OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA USING 3-(4-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE | CELGENE CORPORATION | 2017-06-08 | — | — | US | disclosed |
| WO-2017096184-A1 | TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA AND OF NON-HODGKIN'S LYMPHOME USING LENALIDOMIDE | CELGENE CORPORATION (US) | 2017-06-08 | — | — | WO | disclosed |
| WO-2011050962-A1 | ACID ADDITION SALTS OF LENALIDOMIDE | RATIOPHARM GMBH (DE) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157103-A1 | METHODS OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA USING 3-(4-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE | BCL6, BCL3, MALT1 | CRBN 745/4885DDB1 96/4885IKZF3 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.