Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20368738 | 1.00 | TSHR (0.40) | TSHRNPC1MAPK1HDAC3HDAC1 | |
| SCHEMBL18399595 | 1.00 | TSHR (0.40) | TSHRNPC1MAPK1HDAC3HDAC1 | |
| SCHEMBL22018240 | 0.94 | MAPK1 (0.36) | TSHRNPC1MAPK1HDAC3HDAC1 | |
| SCHEMBL21157778 | 0.88 | HDAC3 (0.40) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL18399528 | 0.83 | MAPK1 (0.41) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL19059608 | 0.80 | HDAC3 (0.40) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL22018173 | 0.78 | MAPK1 (0.37) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL22018432 | 0.76 | HDAC3 (0.42) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL22853571 | 0.73 | ABL1 (0.34) | TSHRMAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL20368680 | 0.72 | SMN1; SMN2 (0.44) | TSHRNPC1MAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849120-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170182017-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170182017-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM2, PIM1, PIM3 | TSHR 1947/4885NPC1 2615/4885MAPK1 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.