Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140395 | 0.82 | MAPT (0.46) | MAPTMAPK1TDP1ALDH1A1MEN1 | |
| SCHEMBL5188249 | 0.78 | MAPT (0.40) | MAPTMAPK1TDP1ALDH1A1ALDH1A3 | |
| SCHEMBL1906183 | 0.77 | MAPT (0.45) | MAPTMAPK1TDP1ALDH1A1MEN1 | |
| SCHEMBL390184 | 0.76 | MAPT (0.45) | MAPTMAPK1TDP1ALDH1A1MEN1 | |
| SCHEMBL388754 | 0.73 | MAPT (0.44) | MAPTMAPK1TDP1ALDH1A1MEN1 | |
| SCHEMBL23884730 | 0.71 | MAPT (0.55) | MAPTMAPK1TDP1ALDH1A1ALDH1A3 | |
| SCHEMBL30231403 | 0.71 | MAPT (0.55) | MAPTMAPK1TDP1ALDH1A1ALDH1A3 | |
| SCHEMBL23884819 | 0.70 | MAPT (0.58) | MAPTMAPK1TDP1ALDH1A1ALDH1A3 | |
| SCHEMBL389643 | 0.70 | MAPT (0.45) | MAPTMAPK1TDP1ALDH1A1MEN1 | |
| SCHEMBL23884752 | 0.69 | MAPT (0.62) | MAPTMAPK1ALDH1A1ALDH1A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322150-A2 | Method of identifying GLP-1 secretagogues | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |