Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14630693 | 0.83 | EPHX2 (0.58) | EPHX2FAAH | |
| SCHEMBL14630694 | 0.83 | EPHX2 (0.58) | EPHX2FAAH | |
| SCHEMBL16570412 | 0.80 | EPHX2 (0.56) | EPHX2FAAH | |
| SCHEMBL14647010 | 0.77 | KDM1A (0.62) | EPHX2FAAHKDM1AKMT2A | |
| SCHEMBL2647959 | 0.77 | KDM1A (0.62) | EPHX2FAAHKDM1AKMT2A | |
| SCHEMBL22123932 | 0.77 | MEN1 (0.61) | MAPTKDM1AFASNLMNAMEN1 | |
| SCHEMBL15624842 | 0.77 | EPHX2 (0.82) | EPHX2FAAH | |
| SCHEMBL103477 | 0.75 | — | — | |
| SCHEMBL18880078 | 0.75 | SMYD3 (0.47) | EPHX2KDM1AFASNKMT2A | |
| SCHEMBL23067910 | 0.74 | HRH1 (0.53) | EPHX2FAAHKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |