Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22100454 | 0.88 | MAPT (0.85) | MAPTALDH1A1HCAR2ATMTSHR | |
| SCHEMBL25616339 | 0.86 | MAPT (0.60) | MAPTALDH1A1HCAR2ATMFAAH | |
| SCHEMBL3929826 | 0.85 | MAPT (0.68) | MAPTALDH1A1HCAR2ATMTTR | |
| SCHEMBL3929823 | 0.85 | MAPT (0.68) | MAPTALDH1A1HCAR2ATMTTR | |
| SCHEMBL1885350 | 0.84 | MAPT (0.72) | MAPTALDH1A1HCAR2ATMTTR | |
| SCHEMBL2618106 | 0.84 | MAPT (0.72) | MAPTALDH1A1HCAR2ATMTTR | |
| SCHEMBL13966627 | 0.84 | MAPT (0.57) | MAPTALDH1A1HCAR2ATMTSHR | |
| SCHEMBL29131601 | 0.82 | MAPT (0.70) | MAPTALDH1A1HCAR2ATMTSHR | |
| SCHEMBL872986 | 0.82 | MAPT (0.70) | MAPTALDH1A1HCAR2ATMNPSR1 | |
| SCHEMBL872985 | 0.82 | MAPT (0.70) | MAPTALDH1A1HCAR2ATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |