Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20946384 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL5057558 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL5057553 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL30159091 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL4760761 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL19067292 | 1.00 | TOP2A (0.30) | TOP2ADUT | |
| SCHEMBL9147213 | 0.85 | — | — | |
| SCHEMBL23670055 | 0.85 | — | — | |
| SCHEMBL31644526 | 0.85 | — | — | |
| SCHEMBL23669704 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148401-A1 | Compounds and Methods of Use Thereof for Treating Tumors | GEORGETOWN UNIVERSITY | 2018-05-31 | — | — | US | disclosed |
| US-9695108-B2 | Compounds and methods of use thereof for treating tumors | GEORGETOWN UNIVERSITY (US) | 2017-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148401-A1 | Compounds and Methods of Use Thereof for Treating Tumors | VHL, TP53, RHOA | TOP2A 4416/4885DUT 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.