Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.51 |
| ▸ | RAF1 | P04049 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19068913 | 0.87 | RAF1 (0.53) | BRAFRAF1RAB9A | |
| SCHEMBL19068912 | 0.82 | BRAF (0.55) | BRAFRAF1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16034801 | 0.68 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL16035931 | 0.68 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16121499 | 0.67 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL20131047 | 0.67 | HTT (0.74) | RAB9ANPC1SMN1; SMN2KMT2ACASP1 | |
| SCHEMBL23677225 | 0.67 | SMN1; SMN2 (0.70) | BRAFRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3932223 | 0.67 | BRAF (0.71) | BRAFRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL16078173 | 0.67 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL12157463 | 0.67 | TSHR (0.73) | RAB9ASMN1; SMN2KMT2AKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9694016-B2 | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG (CH) | 2017-07-04 | — | — | US | disclosed |