Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | BRD2 | P25440 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19069445 | 0.90 | BRD4 (1.00) | BRD4CYP2C9BRD2 | |
| SCHEMBL16140983 | 0.82 | BRD4 (0.73) | BRD4CYP2C9 | |
| SCHEMBL16111487 | 0.82 | BRD4 (1.00) | BRD4CYP2C9 | |
| SCHEMBL16140991 | 0.80 | BRD4 (1.00) | BRD4CYP2C9 | |
| SCHEMBL17758369 | 0.80 | BRD4 (0.68) | BRD4CYP2C9 | |
| SCHEMBL17758368 | 0.80 | BRD4 (0.68) | BRD4CYP2C9 | |
| SCHEMBL16111268 | 0.76 | BRD4 (1.00) | BRD4CYP2C9BRD2 | |
| SCHEMBL16141005 | 0.75 | BRD4 (1.00) | BRD4CYP2C9BRD2 | |
| SCHEMBL17758375 | 0.75 | BRD4 (1.00) | BRD4CYP2C9 | |
| SCHEMBL16111861 | 0.75 | BRD4 (1.00) | BRD4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717739-B2 | Methods and compositions for inhibition of bromodomain-containing proteins | CONVERGENE LLC (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190345162-A1 | Methods and Compositions for Inhibition of Bromodomain-Containing Proteins | CONVERGENE LLC | 2019-11-14 | — | — | US | disclosed |
| US-10266536-B2 | Methods and compositions for inhibition of bromodomain-containing proteins | CONVERGENE LLC (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180134715-A1 | Methods and Compositions for Inhibition of Bromodomain-Containing Proteins | CONVERGENE LLC | 2018-05-17 | — | — | US | disclosed |
| US-9695179-B2 | Methods and compositions for inhibition of bromodomain-containing proteins | CONVERGENE LLC (US) | 2017-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10717739-B2 | Methods and compositions for inhibition of bromodomain-containing proteins | BRPF3, BRD3, BRDT | BRD4 4/4885CYP2C9 4826/4885BRD2 5/4885 |
| US-20190345162-A1 | Methods and Compositions for Inhibition of Bromodomain-Containing Proteins | BRPF3, BRD3, BRDT | BRD4 4/4885CYP2C9 4826/4885BRD2 5/4885 |
| US-10266536-B2 | Methods and compositions for inhibition of bromodomain-containing proteins | BRPF3, BRD3, BRDT | BRD4 4/4885CYP2C9 4826/4885BRD2 5/4885 |
| US-20180134715-A1 | Methods and Compositions for Inhibition of Bromodomain-Containing Proteins | BRPF3, BRD3, BRDT | BRD4 4/4885CYP2C9 4826/4885BRD2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.