Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | BTK | Q06187 | 12/20 | 1.00 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | ABL2 | P42684 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CSK | P41240 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907374 | 1.00 | SRC (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL14673826 | 0.90 | SRC (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL12675755 | 0.90 | SRC (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL1906312 | 0.89 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL1906314 | 0.89 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL14673550 | 0.86 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL12675759 | 0.86 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL1903259 | 0.86 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL1903262 | 0.86 | BTK (1.00) | SRCBTKEGFRABL1ABL2 | |
| SCHEMBL1903257 | 0.86 | BTK (1.00) | SRCBTKEGFRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505766-B2 | Kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150045343-A1 | KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| US-20150045343-A1 | KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| EP-2558099-A2 | KINASE INHIBITORS | The Regents Of The University Of California, San Francisco (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20130035325-A1 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011060440-A2 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011060440-A2 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035325-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K8 | SRC 84/4885BTK 270/4885EGFR 347/4885 |
| US-20150045343-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K8 | SRC 84/4885BTK 270/4885EGFR 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.