Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202861 | 0.92 | NPC1 (0.55) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL10263551 | 0.90 | NPC1 (0.53) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL15677650 | 0.90 | NPC1 (0.55) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL16579446 | 0.81 | NOTUM (0.55) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL14541588 | 0.79 | NPC1 (0.57) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL2543197 | 0.78 | NPC1 (0.57) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL5520110 | 0.77 | NPC1 (0.58) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL38652165 | 0.76 | NPC1 (0.57) | NPC1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL16156076 | 0.74 | MAPT (0.48) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL16939231 | 0.73 | NPC1 (0.46) | NPC1MEN1KMT2ARAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464645-B1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2017-07-05 | — | — | EP | disclosed |