Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.79 |
| ▸ | NPC1 | O15118 | 5/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | SMYD3 | Q9H7B4 | 11/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079255 | 0.93 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| SCHEMBL19079161 | 0.88 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| Hydrochloric Acid SCHEMBL19064420 | 0.87 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| Hydrochloric Acid SCHEMBL19064418 | 0.87 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| SCHEMBL19079173 | 0.86 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| SCHEMBL19079242 | 0.84 | NPC1 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| SCHEMBL19079406 | 0.80 | SMYD3 (0.60) | RAB9ANPC1SMN1; SMN2SMYD3 | |
| SCHEMBL19079178 | 0.79 | SMN1; SMN2 (0.74) | RAB9ANPC1SMN1; SMN2SMYD3 | |
| SCHEMBL19064427 | 0.76 | NPC1 (0.62) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 | |
| SCHEMBL19064423 | 0.76 | NPC1 (0.62) | RAB9ANPC1SMN1; SMN2ALDH1A1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148650-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-05-14 | — | — | US | disclosed |
| US-10428029-B2 | Isoxazole carboxamide compounds | Epizyme, Inc. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | Epizyme, Inc. (US) | 2017-07-06 | — | — | US | disclosed |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | Epizyme, Inc. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428029-B2 | Isoxazole carboxamide compounds | SMYD3, SMYD2, SNRPD3 | RAB9A 759/4885NPC1 3888/4885SMN1; SMN2 248/4885 |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | SMYD3, SMYD2, SNRPD3 | RAB9A 759/4885NPC1 3888/4885SMN1; SMN2 248/4885 |
| US-20200148650-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SNRPD3 | RAB9A 705/4885NPC1 3842/4885SMN1; SMN2 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.