Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.62 |
| ▸ | HTR2C | P28335 | 9/20 | 0.62 |
| ▸ | HTR2B | P41595 | 8/20 | 0.51 |
| ▸ | PNMT | P11086 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757689 | 0.81 | HTR2A (0.71) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| Hydrochloric Acid SCHEMBL27967632 | 0.79 | HTR2A (0.69) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL2368756 | 0.77 | HTR2A (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL6298572 | 0.75 | HTR2A (0.73) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL2695344 | 0.74 | HTR2A (0.71) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| Water SCHEMBL16701244 | 0.74 | HTR2A (0.71) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL2477900 | 0.69 | HTR2A (0.58) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL173414 | 0.69 | HTR2A (0.58) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL2881688 | 0.69 | HTR2C (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL29676733 | 0.69 | HTR2C (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322162-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |