Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079727 | 0.84 | CYP1A2 (0.50) | POLBSLC22A12ALDH1A1LMNAMAPT | |
| SCHEMBL19079722 | 0.83 | POLB (0.47) | POLBSLC22A12PDE4DLMNA | |
| SCHEMBL19079769 | 0.82 | PDE4D (0.68) | POLBSLC22A12PDE4DALDH1A1LMNA | |
| SCHEMBL19079683 | 0.81 | APOBEC3A (0.52) | POLBSLC22A12ALDH1A1LMNAMAPT | |
| SCHEMBL19079721 | 0.81 | POLB (0.45) | POLBSLC22A12PDE4DLMNAMAPT | |
| SCHEMBL19079772 | 0.81 | KMT2A (0.47) | POLBSLC22A12ALDH1A1MAPT | |
| SCHEMBL19079770 | 0.64 | PDE4D (0.71) | POLBSLC22A12PDE4DALDH1A1LMNA | |
| SCHEMBL19079691 | 0.63 | PDE4D (1.00) | POLBSLC22A12PDE4DALDH1A1LMNA | |
| SCHEMBL24029049 | 0.62 | POLB (0.66) | POLBSLC22A12PDE4DALDH1A1 | |
| SCHEMBL1945254 | 0.61 | MEN1 (0.55) | POLBALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | VANDERBILT UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329304-B2 | Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase | PDE4A, PDE4B, PDE7A | POLB 2192/4885SLC22A12 4750/4885PDE4D 6/4885 |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | POLB 2192/4885SLC22A12 4750/4885PDE4D 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.