Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319348 | 0.75 | CYP1A2 (0.55) | GRM5FFAR1APPMAPT | |
| SCHEMBL30772300 | 0.75 | CYP1A2 (0.55) | GRM5FFAR1APPMAPT | |
| SCHEMBL16466525 | 0.75 | GRM5 (0.52) | GRM5FFAR1APPMAPT | |
| SCHEMBL2520705 | 0.75 | GRM5 (0.52) | GRM5FFAR1APPMAPT | |
| SCHEMBL1644125 | 0.75 | GRM5 (0.57) | GRM5FFAR1APPMAPT | |
| SCHEMBL1642511 | 0.75 | PIK3CA (0.56) | GRM5FFAR1APPMAPT | |
| SCHEMBL10847901 | 0.75 | FFAR1 (0.57) | GRM5FFAR1APPMAPT | |
| SCHEMBL28536669 | 0.75 | FFAR1 (0.47) | GRM5FFAR1APPMAPT | |
| SCHEMBL2114741 | 0.74 | APP (0.92) | GRM5FFAR1APPMAPTCA12 | |
| SCHEMBL1230922 | 0.72 | APP (0.67) | GRM5FFAR1APPMAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493856-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | F. Hoffmann-La Roche AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051201-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-05 | — | — | WO | disclosed |