⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721890 | 0.96 | — | — | |
| SCHEMBL8769471 | 0.89 | — | — | |
| SCHEMBL5986206 | 0.87 | — | — | |
| SCHEMBL4500421 | 0.84 | — | — | |
| SCHEMBL16288850 | 0.84 | — | — | |
| SCHEMBL3923587 | 0.82 | — | — | |
| SCHEMBL8769470 | 0.82 | — | — | |
| SCHEMBL693375 | 0.79 | — | — | |
| SCHEMBL16287908 | 0.79 | — | — | |
| SCHEMBL270841 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784076-A1 | Dimeric SMAC mimetics | Joyant Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| EP-2493879-B1 | DIMERIC SMAC MIMETICS | JOYANT PHARMACEUTICALS INC (US) | 2014-05-14 | — | — | EP | disclosed |
| US-20140127155-A1 | Smac mimetic dimers and trimers useful as anti-cancer agents | JOYANT PHARMACEUTICALS, INC (US) | 2014-05-08 | — | — | US | disclosed |
| US-8642554-B2 | Smac mimetic dimers and trimers useful as anti-cancer agents | JOYANT PHARMACEUTICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130344026-A1 | Dimeric Smac Mimetics | JOYANT PHARMACEUTICALS, INC. | 2013-12-26 | — | — | US | disclosed |
| US-8551955-B2 | Dimeric Smac mimetics | JOYANT PHARMACEUTICALS, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2493879-A2 | DIMERIC SMAC MIMETICS | Joyant Pharmaceuticals, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110195043-A1 | Dimeric Smac Mimetics | JOYANT PHARMACEUTICALS, INC. | 2011-08-11 | — | — | US | disclosed |
| WO-2011059763-A2 | DIMERIC SMAC MIMETICS | JOYANT PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| EP-2079309-A1 | SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS | Joyant Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| US-20090104151-A1 | SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS | JOYANT PHARMACEUTICALS, INC (US) | 2009-04-23 | — | — | US | disclosed |
| WO-2008128121-A1 | SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS | JOYANT PHARMACEUTICALS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |