Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.48 |
| ▸ | AKT2 | P31751 | 7/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.48 |
| ▸ | ATR | Q13535 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902022 | 0.96 | AKT1 (0.49) | AKT1AKT2CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1908337 | 0.88 | AKT1 (0.39) | AKT1AKT2CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1900959 | 0.87 | AKT1 (0.52) | AKT1AKT2CYP2D6CYP2C9AKT3 | |
| SCHEMBL1903012 | 0.82 | AKT1 (0.51) | AKT1AKT2ATR | |
| SCHEMBL1902768 | 0.81 | NPC1 (0.42) | AKT1AKT2CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1905644 | 0.80 | AKT1 (0.51) | AKT1AKT2 | |
| SCHEMBL1904321 | 0.79 | AKT1 (0.47) | AKT1AKT2 | |
| SCHEMBL1900984 | 0.78 | AKT1 (0.40) | AKT1AKT2ATRGSK3B | |
| SCHEMBL1907297 | 0.77 | AKT1 (0.53) | AKT1AKT2 | |
| SCHEMBL1903876 | 0.75 | AKT1 (0.50) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | claimed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | claimed |