Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 4/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14118930 | 0.89 | TACR3 (0.37) | AKT1MAPTPDE2ANPC1RAB9A | |
| SCHEMBL14118927 | 0.89 | TACR3 (0.37) | AKT1MAPTPDE2ANPC1RAB9A | |
| SCHEMBL1907534 | 0.88 | AKT1 (0.44) | AKT1AKT2KITSMN1; SMN2ALDH1A1 | |
| SCHEMBL1905670 | 0.80 | AKT1 (0.47) | AKT1AKT2 | |
| SCHEMBL12095371 | 0.80 | AKT1 (0.34) | AKT1AKT2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1907910 | 0.80 | AKT1 (0.42) | AKT1AKT2KITSMN1; SMN2MAPT | |
| SCHEMBL1534681 | 0.79 | AKT1 (0.44) | AKT1AKT2KITALDH1A1CNR1 | |
| SCHEMBL1903104 | 0.79 | AKT1 (0.44) | AKT1AKT2KITCNR1CNR2 | |
| SCHEMBL1535047 | 0.77 | AKT1 (0.38) | AKT1AKT2KITSMN1; SMN2GAA | |
| SCHEMBL14118774 | 0.77 | AKT1 (0.41) | AKT1AKT2KITCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |