Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.65 |
| ▸ | CCL2 | P13500 | 2/20 | 0.52 |
| ▸ | BRD2 | P25440 | 7/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11907037 | 1.00 | BRD4 (0.65) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13824045 | 0.90 | BRD4 (0.54) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL13726668 | 0.88 | BRD4 (0.73) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL11907638 | 0.85 | BRD4 (0.51) | BRD4BRD2BRD3 | |
| SCHEMBL11907753 | 0.85 | BRD4 (0.54) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL1905251 | 0.82 | BRD4 (0.76) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL1904607 | 0.82 | BRD4 (0.76) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15437260 | 0.81 | BRD4 (0.75) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL15450338 | 0.81 | BRD4 (0.68) | BRD4CCL2BRD2BRD3 | |
| SCHEMBL11907215 | 0.81 | BRD4 (0.60) | BRD4CCL2BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496558-A1 | THETRAHYDROQUINOLINES DERIVATIVES AS BROMODOMAIN INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054848-A1 | THETRAHYDROQUINOLINES DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |