Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.81 |
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.81 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.63 |
| ▸ | TRAP1 | Q12931 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1219609 | 0.90 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1219606 | 0.90 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL16161869 | 0.89 | HSP90AB1 (0.80) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220841 | 0.88 | HSP90AA1 (0.85) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220380 | 0.88 | HSP90AA1 (0.85) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL16161783 | 0.88 | HSP90AA1 (0.81) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL38654958 | 0.88 | HSP90AA1 (0.81) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1219082 | 0.88 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL8122876 | 0.87 | HSP90AA1 (0.82) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220579 | 0.87 | HSP90AA1 (0.80) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380879-B1 | Tetrahydroindolone and tetrahydroindazolone derivatives | ESANEX INC (US) | 2017-07-12 | — | — | EP | claimed |