Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19612191 | 0.87 | MAPT (1.00) | TDP1L3MBTL1MAPTMAPK1HTR6 | |
| SCHEMBL9340084 | 0.86 | MAPT (0.65) | TDP1L3MBTL1MAPTMAPK1HTR6 | |
| SCHEMBL31725934 | 0.86 | MAPT (0.65) | TDP1L3MBTL1MAPTMAPK1HTR6 | |
| SCHEMBL1028222 | 0.83 | MAPT (0.53) | TDP1L3MBTL1MAPTMAPK1HTR1A | |
| SCHEMBL29414783 | 0.83 | MAPT (0.59) | TDP1L3MBTL1MAPTMAPK1LIPE | |
| SCHEMBL1081189 | 0.83 | MAPT (0.59) | TDP1L3MBTL1MAPTMAPK1LIPE | |
| SCHEMBL2880443 | 0.81 | MAPT (0.81) | TDP1L3MBTL1MAPTMAPK1HTR6 | |
| SCHEMBL18171750 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1MAPTMAPK1LIPE | |
| SCHEMBL20539690 | 0.81 | MAOB (0.50) | TDP1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL1513408 | 0.81 | MAPT (0.57) | TDP1L3MBTL1MAPTMAPK1LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| EP-3400213-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | PDCD1, CD274, PDCD1LG2 | TDP1 1926/4885L3MBTL1 1347/4885MAPT 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.