⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695993 | 0.83 | KDM4E (0.32) | — | |
| SCHEMBL23131296 | 0.79 | — | — | |
| SCHEMBL3698711 | 0.69 | — | — | |
| SCHEMBL24486045 | 0.68 | KDM4E (0.49) | — | |
| SCHEMBL3783399 | 0.68 | PDK2 (0.38) | — | |
| SCHEMBL6855320 | 0.67 | ADORA1 (0.43) | — | |
| SCHEMBL1406317 | 0.66 | — | — | |
| SCHEMBL23214301 | 0.66 | — | — | |
| SCHEMBL22427780 | 0.66 | — | — | |
| SCHEMBL553364 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352340-B2 | Pyridine and pyridimine compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-20170190689-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-07-06 | — | — | US | disclosed |