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SCHEMBL19097481

SCHEMBL19097481

CCOC(=O)c1cnn(-c2cccc(-c3sccc3COc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3C)n2)c1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ GUCY1A1 Q02108 17/20 0.59
▸ GUCY1B1 Q02153 17/20 0.59
▸ TP53 P04637 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ MEN1 O00255 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19097476 0.94 GUCY1A1 (0.60) GUCY1A1GUCY1B1TP53POLBMEN1
SCHEMBL19103547 0.93 GUCY1A1 (0.54) GUCY1A1GUCY1B1TP53POLBMEN1
SCHEMBL17398151 0.93 GUCY1A1 (0.61) GUCY1A1GUCY1B1MEN1ALDH1A1GAA
SCHEMBL19097547 0.91 GUCY1A1 (0.63) GUCY1A1GUCY1B1TP53POLBMEN1
SCHEMBL17398161 0.90 GUCY1A1 (0.58) GUCY1A1GUCY1B1MEN1ALDH1A1GAA
SCHEMBL19097552 0.90 GUCY1A1 (0.59) GUCY1A1GUCY1B1TP53POLBMEN1
SCHEMBL17398201 0.90 GUCY1A1 (0.58) GUCY1A1GUCY1B1MEN1ALDH1A1GAA
SCHEMBL17398175 0.89 GUCY1A1 (0.55) GUCY1A1GUCY1B1POLBMEN1ALDH1A1
SCHEMBL17398169 0.89 GUCY1A1 (0.56) GUCY1A1GUCY1B1MEN1ALDH1A1GAA
SCHEMBL19097543 0.88 GUCY1A1 (0.58) GUCY1A1GUCY1B1TP53POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9765067-B2 Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators NOVARTIS AG (CH) 2017-09-19 — — US disclosed
US-9765067-B2 Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators NOVARTIS AG (CH) 2017-09-19 — — US disclosed
US-9765067-B2 Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators NOVARTIS AG (CH) 2017-09-19 — — US disclosed
US-20170197950-A1 THIOPHEN-2-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS NOVARTIS AG (CH) 2017-07-13 — — US disclosed
US-20170197950-A1 THIOPHEN-2-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS NOVARTIS AG (CH) 2017-07-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170197950-A1 THIOPHEN-2-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS GUCY1B2, GUCY1A2, GUCY1A1 GUCY1A1 3/4885GUCY1B1 4/4885TP53 4529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.