Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 20/20 | 0.80 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19099006 | 1.00 | KHK (0.80) | KHKPDE10A | |
| SCHEMBL19051300 | 0.89 | KHK (1.00) | KHKPDE10A | |
| SCHEMBL22697156 | 0.89 | KHK (1.00) | KHKPDE10A | |
| SCHEMBL19051302 | 0.84 | KHK (1.00) | KHKPDE10A | |
| SCHEMBL19024189 | 0.84 | KHK (1.00) | KHKPDE10A | |
| SCHEMBL19024188 | 0.84 | KHK (1.00) | KHKPDE10A | |
| SCHEMBL19024212 | 0.82 | KHK (0.70) | KHKPDE10A | |
| SCHEMBL19024211 | 0.82 | KHK (0.70) | KHKPDE10A | |
| SCHEMBL19024210 | 0.82 | KHK (0.70) | KHKPDE10A | |
| Pf-06835919 SCHEMBL19024093 | 0.82 | KHK (1.00) | KHKPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397631-B1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER (US) | 2021-04-07 | — | — | EP | disclosed |
| WO-2017115205-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS | PFIZER INC. (US) | 2017-07-06 | — | — | WO | disclosed |