SCHEMBL190990

SCHEMBL190990

CCCCn1c(=O)[nH]c(=O)c2[nH]c(C)nc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.59
PDE4A P27815 3/20 0.59
PDE4B Q07343 3/20 0.59
PDE4C Q08493 3/20 0.59
PDE4D Q08499 3/20 0.59
ALDH1A1 P00352 6/20 0.51
ADORA2B P29275 3/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
ADORA1 P30542 2/20 0.51
BRD4 O60885 1/20 0.50
BRD2 P25440 1/20 0.50
BRD3 Q15059 1/20 0.50
BRDT Q58F21 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
HSD17B10 Q99714 3/20 0.49
HPGD P15428 2/20 0.49
LMNA P02545 1/20 0.49
KDM4A O75164 1/20 0.49
TSHR P16473 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13343375 0.95 ADORA2A (0.55) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL13368751 0.94 ADORA2A (0.53) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL7419694 0.85 PDE4A (0.47) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL10963141 0.84 ADORA2A (0.55) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL4626790 0.84 ADORA2A (0.58) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL3178085 0.84 ADORA2A (0.58) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL10873660 0.83 ADORA2A (0.46) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL7621617 0.83 ADORA2A (0.54) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL3848060 0.82 ADORA2A (0.57) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL13368841 0.82 PDE2A (0.47) ADORA2APDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2875126-B1 ERYTHROID PRODUCTION THE COMMON SERVICES AGENCY (GB) 2018-01-17 EP claimed
US-20150203818-A1 ERYTHROID PRODUCTION UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) 2015-07-23 US claimed
EP-2875126-A1 ERYTHROID PRODUCTION The Common Services Agency (GB) 2015-05-27 EP claimed
WO-2014013255-A1 ERYTHROID PRODUCTION THE COMMON SERVICES AGENCY (GB) 2014-01-23 WO claimed
WO-2009131948-A2 HIGH-THROUGHPUT CELL-BASED CFTR ASSAY INSTITUTE FOR ONEWORLD HEALTH (US) 2009-10-29 WO claimed
EP-0956855-B1 Immunosuppressive effects of 8 substituted xanthine derivatives LEUVEN K U RES & DEV (BE) 2003-03-12 EP claimed
EP-0956855-A1 Immunosuppressive effects of 8-substituted xanthine derivatives K.U. Leuven Research & Development (BE) 1999-11-17 EP claimed
US-20250283041-A1 METHODS FOR PRODUCING RED BLOOD CELLS ALBERT EINSTEIN COLLEGE MEDICINE (US) 2025-09-11 US disclosed
EP-4532693-A1 METHODS FOR PRODUCING RED BLOOD CELLS Albert Einstein College of Medicine (US) 2025-04-09 EP disclosed
WO-2023230405-A1 METHODS FOR PRODUCING RED BLOOD CELLS ALBERT EINSTEIN COLLEGE OF MEDICINE (US) 2023-11-30 WO disclosed
EP-2875126-B1 ERYTHROID PRODUCTION THE COMMON SERVICES AGENCY (GB) 2018-01-17 EP disclosed
EP-3247790-A1 CELL MATURATION PROCESS Scottish National Blood Transfusion Service (GB) 2017-11-29 EP disclosed
CN-107029209-A Guanylate cyclase receptor activator for treating tissue inflammation and canceration 药物协和公司 2017-08-11 CN disclosed
US-5470579-A Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation LVMH, RECHERCHE (FR) 1995-11-28 US disclosed
EP-0535038-A4 MAMMALIAN ADIPOGENIC FACTORS 1993-12-29 EP disclosed
EP-0535038-A1 MAMMALIAN ADIPOGENIC FACTORS W. ALTON JONES CELL SCIENCE CENTER (US) 1993-04-07 EP disclosed
WO-1991018924-A1 MAMMALIAN ADIPOGENIC FACTORS W. ALTON JONES CELL SCIENCE CENTER (US) 1991-12-12 WO disclosed
EP-0308460-A1 A COMPOSITION FOR THE TOPICAL TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION. PHARMACIA AB (SE) 1989-03-29 EP disclosed
WO-1988007380-A1 A COMPOSITION FOR THE TOPICAL TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION PHARMACIA AB (SE) 1988-10-06 WO disclosed
EP-0039780-A1 Di- or trisubstituted xanthines with neuroleptic activity, process for their preparation and pharmaceutical preparations containing them SOCIETE DES PRODUITS NESTLE S.A. (CH) 1981-11-18 EP disclosed