Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19101564 | 0.91 | BRD4 (0.38) | FGFR3KDRFGFR1PTK2LCK | |
| SCHEMBL19101589 | 0.90 | FGFR3 (0.40) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL17470090 | 0.86 | FGFR3 (0.46) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL19101531 | 0.84 | FGFR3 (0.41) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL16053170 | 0.83 | FGFR1 (0.48) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL19101625 | 0.83 | FGFR4 (0.39) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL19101534 | 0.83 | FGFR3 (0.37) | FGFR3KDRKCNH2FGFR1FGFR4 | |
| SCHEMBL19101575 | 0.82 | FGFR3 (0.41) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL17470015 | 0.82 | FGFR3 (0.43) | FGFR3KDRKCNH2FGFR1FGFR2 | |
| SCHEMBL19101602 | 0.82 | FGFR3 (0.47) | FGFR3KCNH2FGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701680-B2 | Pyrimidine and pyridine compounds and their usage | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-07-11 | — | — | US | disclosed |