Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | JAK3 | P52333 | 7/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069924 | 0.89 | FGFR4 (0.44) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16069732 | 0.85 | FGFR4 (0.44) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16069925 | 0.84 | FGFR3 (0.47) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL19101567 | 0.84 | FGFR3 (0.50) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16070187 | 0.83 | FGFR3 (0.47) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL19101508 | 0.83 | FGFR3 (0.42) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16069931 | 0.80 | FGFR3 (0.53) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16070158 | 0.79 | FGFR3 (0.62) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16070183 | 0.78 | FGFR3 (0.53) | FGFR3FGFR2FGFR4FGFR1KCNH2 | |
| SCHEMBL16069851 | 0.78 | FGFR3 (0.41) | FGFR3FGFR2FLT4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701680-B2 | Pyrimidine and pyridine compounds and their usage | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-07-11 | — | — | US | disclosed |