Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19390970 | 1.00 | GRIN2B (0.52) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL3375289 | 0.89 | GRIN2B (0.61) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL32688193 | 0.84 | SLC6A2 (0.49) | GRIN2BSLC18A3ALDH1A1TSHRKDM4E | |
| SCHEMBL11251947 | 0.83 | HRH3 (0.67) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL13744978 | 0.82 | GRIN2B (0.55) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL14506713 | 0.82 | GRIN2B (0.55) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL12680890 | 0.82 | GRIN2B (0.55) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| Bromide SCHEMBL11253051 | 0.82 | HRH3 (0.65) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL531089 | 0.82 | HRH3 (0.70) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 | |
| SCHEMBL16367134 | 0.81 | GRIN2B (0.54) | GRIN2BHRH4HRH3SLC18A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701666-B2 | 1,4-pyridone bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-07-11 | — | — | US | disclosed |