Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17373101 | 0.93 | EGFR (0.81) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103435 | 0.90 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103395 | 0.88 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103463 | 0.87 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103464 | 0.87 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103465 | 0.86 | EGFR (0.88) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103482 | 0.85 | EGFR (0.88) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19320682 | 0.85 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19103307 | 0.85 | EGFR (0.51) | EGFRERBB2ERBB3ERBB4KCNH2 | |
| SCHEMBL19320685 | 0.85 | EGFR (0.67) | EGFRKCNH2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796712-B2 | Heteroaryl compounds for kinase inhibition | ARIAD PHARMACEUTICALS, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170253594-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-09-07 | — | — | US | disclosed |
| US-20170197962-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197962-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ERBB2, EGFR, ERBB3 | EGFR 2/4885ERBB2 1/4885ERBB3 3/4885 |
| US-20170253594-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ERBB2, EGFR, ERBB3 | EGFR 2/4885ERBB2 1/4885ERBB3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.