Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 19/20 | 0.50 |
| ▸ | PIM1 | P11309 | 19/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 19/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906088 | 0.88 | PIM3 (0.54) | PIM3PIM1PIM2 | |
| SCHEMBL1910942 | 0.84 | PIM3 (0.58) | PIM3PIM1PIM2 | |
| SCHEMBL14906187 | 0.83 | PIM3 (0.55) | PIM3PIM1PIM2 | |
| SCHEMBL1911133 | 0.82 | PIM2 (0.54) | PIM3PIM1PIM2 | |
| SCHEMBL10278514 | 0.81 | PIM3 (0.54) | PIM3PIM1PIM2 | |
| SCHEMBL14891716 | 0.78 | CYP3A4 (0.50) | PIM3PIM1PIM2 | |
| SCHEMBL1910893 | 0.75 | PIM2 (0.54) | PIM3PIM1PIM2 | |
| SCHEMBL1911184 | 0.74 | PIM1 (0.57) | PIM3PIM1PIM2 | |
| SCHEMBL1911129 | 0.71 | PIM1 (0.48) | PIM3PIM1PIM2 | |
| SCHEMBL1910897 | 0.71 | CYP3A4 (0.50) | PIM3PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |