Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.64 |
| ▸ | CACNA1I | Q9P0X4 | 10/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269237 | 0.92 | KCNH2 (0.64) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4274637 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4279329 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4274259 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4274233 | 0.91 | KCNH2 (0.62) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4275245 | 0.90 | KCNH2 (0.65) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4272256 | 0.90 | KCNH2 (0.65) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4273219 | 0.90 | KCNH2 (0.61) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4285626 | 0.89 | KCNH2 (0.61) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 | |
| SCHEMBL4270195 | 0.89 | KCNH2 (0.61) | KCNH2CACNA1ICACNA1GCACNA1HMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |