Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 15/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269502 | 0.93 | KCNH2 (0.60) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL20056435 | 0.91 | CACNA1I (0.51) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4283918 | 0.89 | KCNH2 (0.51) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL20056198 | 0.87 | KCNH2 (0.56) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL4275239 | 0.87 | KCNH2 (0.49) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4280767 | 0.86 | KCNH2 (0.67) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 | |
| SCHEMBL4271103 | 0.85 | CACNA1I (0.60) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4279194 | 0.84 | ACKR3 (0.48) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4283872 | 0.83 | CACNA1I (0.68) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4276548 | 0.82 | KCNH2 (0.70) | CACNA1IKCNH2CACNA1HCYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |