Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 14/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19112992 | 0.90 | CACNA1I (0.47) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4269196 | 0.88 | CACNA1I (0.46) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4275836 | 0.88 | CACNA1I (0.46) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4270993 | 0.87 | CACNA1I (0.45) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL19113214 | 0.86 | KCNH2 (0.44) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4278887 | 0.86 | CACNA1I (0.46) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4272368 | 0.86 | CACNA1I (0.44) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4282732 | 0.86 | CACNA1I (0.44) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4273159 | 0.86 | CACNA1I (0.49) | CACNA1IKCNH2NPC1RAB9ACACNA1H | |
| SCHEMBL4275588 | 0.86 | CACNA1I (0.45) | CACNA1IKCNH2NPC1RAB9ACACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |