Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276605 | 0.92 | KCNH2 (0.58) | KCNH2CACNA1ICACNA1GCACNA1HRORC | |
| SCHEMBL13569753 | 0.90 | KCNH2 (0.47) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL4275245 | 0.86 | KCNH2 (0.65) | KCNH2CACNA1ICACNA1GCACNA1HRORC | |
| SCHEMBL4272256 | 0.86 | KCNH2 (0.65) | KCNH2CACNA1ICACNA1GCACNA1HRORC | |
| SCHEMBL19112606 | 0.84 | CACNA1I (0.42) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL4274763 | 0.82 | KCNH2 (0.57) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL4271076 | 0.82 | KCNH2 (0.55) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL19113096 | 0.82 | KCNH2 (0.60) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL4277349 | 0.81 | KCNH2 (0.56) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 | |
| SCHEMBL4275313 | 0.81 | KCNH2 (0.56) | KCNH2CACNA1ICACNA1GCACNA1HCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |