Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.47 |
| ▸ | PIM1 | P11309 | 16/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 16/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10278603 | 0.83 | CYP3A4 (0.49) | PIM2PIM1PIM3GSK3BCYP3A4 | |
| SCHEMBL10278517 | 0.82 | PIM1 (0.46) | PIM2PIM1PIM3GSK3BCYP3A4 | |
| SCHEMBL1911287 | 0.81 | PIM2 (0.53) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL319247 | 0.81 | PIM2 (0.56) | PIM2PIM1PIM3GSK3BCYP3A4 | |
| SCHEMBL1911163 | 0.75 | PIM1 (0.48) | PIM2PIM1PIM3GSK3BCYP3A4 | |
| SCHEMBL14892221 | 0.73 | PIM1 (0.68) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL14892377 | 0.73 | PIM1 (0.68) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL1911197 | 0.73 | PIM1 (0.64) | PIM2PIM1PIM3 | |
| SCHEMBL1911195 | 0.73 | PIM1 (0.64) | PIM2PIM1PIM3GSK3B | |
| SCHEMBL1911228 | 0.73 | GSK3B (0.56) | PIM2GSK3BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |