Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 16/20 | 0.67 |
| ▸ | ROS1 | P08922 | 5/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | INSR | P06213 | 2/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.66 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.66 |
| ▸ | STK25 | O00506 | 1/20 | 0.66 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | CASK | O14936 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12729038 | 0.93 | ZAP70 (0.70) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12729045 | 0.93 | ZAP70 (0.70) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12892751 | 0.90 | ALK (0.75) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12780070 | 0.90 | ZAP70 (0.77) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12892749 | 0.90 | ALK (0.75) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL14981305 | 0.89 | ALK (0.74) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12781758 | 0.88 | ALK (0.78) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12780077 | 0.87 | ZAP70 (0.74) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12892763 | 0.87 | ALK (0.77) | ZAP70ALKROS1EGFRINSR | |
| SCHEMBL12781735 | 0.86 | ALK (0.88) | ZAP70ALKROS1EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |