Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.73 |
| ▸ | INSR | P06213 | 13/20 | 0.73 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20085649 | 0.84 | ALK (1.00) | ALKINSR | |
| SCHEMBL20085724 | 0.83 | ALK (1.00) | ALKINSR | |
| SCHEMBL12892750 | 0.82 | ALK (0.62) | ALKINSREGFR | |
| SCHEMBL12780219 | 0.82 | ALK (0.71) | ALKINSREGFR | |
| SCHEMBL12918397 | 0.81 | AXL (0.56) | ALKINSREGFR | |
| SCHEMBL14981305 | 0.80 | ALK (0.74) | ALKINSREGFR | |
| SCHEMBL20085674 | 0.79 | ALK (1.00) | ALKINSR | |
| SCHEMBL12892751 | 0.77 | ALK (0.75) | ALKINSREGFR | |
| SCHEMBL12892749 | 0.77 | ALK (0.75) | ALKINSREGFR | |
| SCHEMBL18877727 | 0.77 | ALK (0.85) | ALKINSREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |