Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 10/20 | 0.58 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | MC3R | P41968 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19100423 | 0.89 | EGFR (0.67) | EGFRERBB2ERBB4JAK3GAK | |
| Maleic Acid SCHEMBL20637506 | 0.87 | EGFR (0.64) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100190 | 0.84 | EGFR (0.67) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100063 | 0.83 | EGFR (0.67) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19123928 | 0.81 | EGFR (0.63) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100269 | 0.81 | EGFR (0.64) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100094 | 0.80 | EGFR (0.66) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100301 | 0.78 | EGFR (0.85) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19124118 | 0.78 | EGFR (0.73) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL19100459 | 0.77 | EGFR (0.70) | EGFRERBB2ERBB4JAK3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017117680-A1 | NOVEL FLUORINATED QUINAZOLINE DERIVATIVES AS EGFR INHIBITORS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-07-13 | — | — | WO | disclosed |