Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648043 | 1.00 | C5AR1 (0.60) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL650905 | 0.95 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL651497 | 0.95 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL651831 | 0.90 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL650902 | 0.90 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL4770465 | 0.89 | C5AR1 (0.69) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL651559 | 0.87 | C5AR1 (0.62) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL1912912 | 0.87 | C5AR1 (0.62) | C5AR1SMN1; SMN2LMNAL3MBTL1GBA1 | |
| SCHEMBL651003 | 0.84 | C5AR1 (0.63) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL5072359 | 0.84 | C5AR1 (0.62) | C5AR1SMN1; SMN2LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |