Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19132331 | 0.91 | MAPT (0.56) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL19132310 | 0.89 | MAPT (0.54) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL19916692 | 0.88 | MAPT (0.56) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL12481925 | 0.87 | MAPT (0.65) | MAPTLMNATP53MEN1HTT | |
| SCHEMBL15424153 | 0.87 | MAPT (0.59) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL12480937 | 0.85 | MAPT (0.56) | MAPTLMNAMEN1HTTKMT2A | |
| SCHEMBL19685586 | 0.85 | MAPT (0.53) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL12481161 | 0.84 | MAPT (0.54) | MAPTLMNAMEN1HTTKMT2A | |
| SCHEMBL15424141 | 0.84 | MAPT (0.60) | MAPTLMNATP53RXFP1MEN1 | |
| SCHEMBL12480897 | 0.84 | MAPT (0.60) | MAPTLMNATP53RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708299-B2 | Hedgehog antagonists having zinc binding moieties | GENENTECH, INC. (US) | 2017-07-18 | — | — | US | disclosed |