Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22110566 | 0.83 | POLB (0.54) | POLBHSD17B10TSHRRECQLL3MBTL1 | |
| SCHEMBL13024644 | 0.83 | MAPT (0.58) | POLBTSHRMAPTTP53SMN1; SMN2 | |
| SCHEMBL20676094 | 0.81 | POLB (0.47) | POLBHSD17B10TSHRRECQLL3MBTL1 | |
| SCHEMBL27730024 | 0.74 | CHEK1 (0.56) | CHEK1AURKADAPK3CSNK1A1GSK3A | |
| SCHEMBL13024651 | 0.74 | MAPT (0.58) | POLBTSHRMAPTTP53SMN1; SMN2 | |
| SCHEMBL655559 | 0.74 | CHEK1 (0.54) | HSD17B10CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL26356567 | 0.74 | CHEK1 (0.54) | NPSR1CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL13727580 | 0.74 | CHEK1 (0.54) | POLBTSHRL3MBTL1CHEK1AURKA | |
| SCHEMBL19128045 | 0.71 | HDAC1 (0.48) | F2CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL2925874 | 0.69 | CHEK1 (0.50) | CHEK1AURKADAPK3CSNK1A1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |